Phenylbutazone, often referred to as “bute,” is a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term treatment of pain and fever in animals. Here are some important points about phenylbutazone:

• Uses:

  • In Humans:

    • Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949.

    • However, it is no longer approved or marketed for any human use in the United States.

    • In the UK, it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.

  • In Horses:

    • Phenylbutazone is the most commonly used NSAID for horses in the United States.

    • It is used for the following purposes:

      • Analgesia: Pain relief from infections and musculoskeletal disorders, including sprains, overuse injuries, tendinitis, arthralgias, arthritis, and laminitis.

      • Antipyresis: Reduction of fevers.